At the start of the year, the pair scrapped a whole album of similar fare, enlisted singer James Buttery, and created a series of slow burning, nocturnal odes to love, loss and the problem of place. It is the product of toil by displaced northern Englishmen, Cheshire-born James Young and Yorkshire-born Aiden Whalley, the duo behind Darkstar's breakthrough song, last year's romantic, glitchy 2-step dancefloor number 'Aidy's Girl Is A Computer'.
Because, while bedrooms are vital to the planning and execution of the majority of today's more interesting music, one needs to take a look outside to have a chance of creating something as pure and definite as North by Darkstar. As locally-specific scenes lose their importance, is geography now becoming a defunct term in the musical lexicon? Or is place, conversely, more important than ever in understanding music, its melancholic forms, its potency? I'm sticking with the latter. "What we want to do eventually is to use the new knowledge generated from this project to make better antibiotics based on silver nanoparticles," said Wang.The question whether music can still be concerned with place in an internet age that has, to some extent, devoured both, is one that has triggered much debate in articles such as this one by fellow Quietus scribe Hazel Sheffield. The National Science Foundation-funded study validated the idea of investigating the dynamics of single proteins in live bacteria, said Wang, an approach that could help researchers understand the real-time responses of bacteria to silver nanoparticles, which have been proposed for fighting against so-called "superbugs" that are resistant to commonly prescribed antibiotics.
Their approach, now patent pending, was to put strain on DNA strands by bending them, thus making them more susceptible to interactions with other chemicals, including silver ions. The observation of DNA separation caused by silver ions came from earlier work that Wang and colleagues had done with bent DNA. In contrast, when treated with silver, the proteins fall off from the DNA, moving by themselves and thus faster." "When the protein is bound to the DNA, it moves slowly together with the DNA, which is a huge molecule in the bacteria. "Then the faster dynamics of the proteins caused by silver can be understood," said Wang. The researchers observed that silver ions were causing paired strands of DNA in the bacteria to separate, and the binding between the protein and the DNA to weaken. But, surprisingly, we found that the dynamics of this protein became faster." "It is known that silver ions can suppress and kill bacteria we thus expected that everything slowed down in the bacteria when treated with silver. Researchers were surprised to find that silver ions actually sped up the dynamics of the protein, opposite of what they thought would happen. Instead, Wang and his colleagues used an advanced imaging technique, called single-particle-tracking photoactivated localization microscopy, to watch and track a particular protein found in E. While these methods are effective, they typically produce only snapshots in time, said Yong Wang, assistant professor of physics and an author of the study, published in the journal Applied and Environmental Microbiology. Traditionally, the antimicrobial effects of silver have been measured through bioassays, which compare the effect of a substance on a test organism against a standard, untreated preparation.
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